Hypoxia. 2. Hypoxia regulates cellular metabolism

Hypoxia. 2. Hypoxia regulates cellular metabolism.

Adaptation to lowering oxygen levels (hypoxia) requires coordinated downregulation of metabolic demand and supply to prevent a mismatch in ATP utilization and production that might culminate in a bioenergetic collapse. Hypoxia diminishes ATP utilization by downregulating protein translation and the activity of the Na-K-ATPase. Hypoxia diminishes ATP production in part by lowering the activity o...

Hypoxia metabolism in ageing

supply to tissues and a reduction in tissue pO 2. A diminished vascularization in ageing alters the diffusion of O 2 at the capillary tissue level, and at an advanced stage, this can lead to tissue hypoxia. Molecular O 2 sensors mediate the response to O 2 deprivation through the regulation of protein expression, enzyme activities, and metabolic regulating factors [1]. HIF1α is perhaps the best...

Inflammation Hypoxia Regulates Macrophage Functions in

Hypoxia regulates the natriuretic peptide system.

Numerous clinical studies have addressed the role of the natriuretic peptide system either as a diagnostic tool or as a guide to treatment in many cardiac diseases. The concept behind these studies has been that intravascular overload produces cardiac wall stress that alone stimulates the synthesis and release of natriuretic peptides the result of which is diuresis, natriuresis, and vasodilatat...

Hypoxia regulates RNA splicing of HIF targets

Hypoxia or reduced oxygen level is frequently observed in solid tumors. Hypoxia plays a significant role in solid tumor progression and metastasis by stabilizing hypoxia inducible factor (HIF) to activate gene transcription. The majority of human genes are alternatively spliced, producing RNA isoforms that code for functionally distinct proteins. Thus, it is unclear if HIF promotes tumor progre...